Study on the changes of blood glucose in hemodialysis patients with diabetes

SUMMARY OBJECTIVE: The aims of this study were to observe the regularity of blood glucose changes in hemodialysis patients with diabetes, time of onset of hypoglycemia and blood glucose level during dialysis, and to explore the sensitive early warning indicators of hypoglycemia in dialysis patients. BACKGROUND: Diabetes patients have a high incidence of hypoglycemia during hemodialysis. METHODS: A total of 124 maintenance hemodialysis patients with diabetes were selected for this study. Before dialysis, one, two, and three h after dialysis, and when hypoglycemia symptoms occurred, the blood glucose changes were monitored, the blood glucose drop range was observed when hypoglycemia symptoms occurred, and the correlation between the two was analyzed. RESULTS: After the start of the dialysis, the patient's blood glucose showed a downward trend. The symptoms of hypoglycemia were most obvious within one-two hours, with an incidence rate of 57.9%. When the blood glucose drop percentage reached 37.7%, the specificity and sensitivity of early warning hypoglycemia symptoms were 84.6 and 73%, respectively. CONCLUSIONS: For hemodialysis patients with diabetes, attention should be paid to the symptoms of hypoglycemia during dialysis, and blood glucose should be monitored before dialysis and after 1-2 h of dialysis. If the blood glucose drop percentage is greater than 37.7%, the timely measures should be taken.

Hígado agudo graso del embarazo: reporte de caso / Acute fatty liver of pregnancy: case report

El hígado graso del embarazo es una patología poco frecuente en la especialidad obstétrica, cuyo diagnóstico se realiza basado en los criterios de Swansea, muchas veces es un diagnóstico que se realiza por exclusión; usualmente se presenta entre las semanas 30 y 35 del embarazo, y la cura definitiva se realiza con la interrupción expedita del mismo; con una tasa de recuperación casi del 100% si se realiza la interrupción oportuna y una tasa de mortalidad materno fetal actual del 10%. Es importante estar atentos a la ganancia ponderal de la embarazada durante el control prenatal, la epigastralgia, y los signos clínicos asociados a hipoglicemia(AU)

Fatty liver of pregnancy is a rare pathology in obstetrics, whose diagnosis is made based on the Swansea criteria, many times it is a diagnosis that is made by exclusion; It usually occurs between weeks 30 and 35, and the definitive cure is carried out with the expeditious interruption of pregnancy; with a recovery rate of almost 100% if timely interruption is made and a current maternal-fetal mortality rate of 10%. It is important to be attentive to the weight gain of the pregnant woman during prenatal control, epigastric pain, and clinical signs associated with hypoglycemia

Is biochemical hypoglycemia necessary during an insulin tolerance test?

ABSTRACT Objective The insulin tolerance test (ITT) has been accepted as the gold standard test for assessing the integrity of the growth hormone (GH) - insulin-like growth factor (IGF-1) axis and the hypothalamic-pituitary-adrenal (HPA) axis. The goal of the test is to achieve clinical and biochemical hypoglycemia at a blood glucose level ≤ 40 mg/dL to effectively and correctly assess the HPA and GH-IGF-1 axes. In this study, the GH and cortisol responses of patients who achieved and failed to achieve biochemical hypoglycemia during an ITT were compared. Subjects and methods One hundred thirty-five patients with pituitary disorders were included in the study. Samples for blood glucose levels were obtained after clear symptoms of clinical hypoglycemia developed. The patients were enrolled in the hypoglycemic and nonhypoglycemic groups according to whether their plasma glucose level ≤ 40 mg/dL or > 40 mg/dL during an ITT, and the groups were compared in terms of their GH and cortisol responses. Results The mean age, body mass index and waist circumference of the two patient groups were found to be similar. The mean blood glucose level was significantly lower in the hypoglycemic group than in the nonhypoglycemic group (19.3 and 52.0 mg/dL, respectively). When the two groups were compared in terms of peak cortisol and GH responses, no statistically significant differences were found. Conclusion The data presented suggest that clinically symptomatic hypoglycemia is as effective as biochemically confirmed hypoglycemia during an ITT. Arch Endocrinol Metab. 2020;64(1):82-8

Hipoglicemia e seus fatores de risco na infusão contínua de insulina em pacientes críticos / Hipoglucemia y sus factores de riesgo en la administración continua de insulina en pacientes críticos / Hypoglycemia and Associated Risk Factors during Continuous Insulin Administration in Critically-ill Patients

RESUMO Introdução: A hipoglicemia é o efeito adverso mais importante em pacientes submetidos a terapia com insulina intravenosa na unidade de terapia intensiva, devido ao seu difícil controle pelos profissionais de saúde, sendo também associado a outros fatores de risco clínicos e patológicos. Objetivo: Identificar na literatura os fatores de risco de hipoglicemia durante a infusão contínua de insulina intravenosa. Métodos: Estudo de revisão de literatura integrativa. A coleta de dados foi realizada através do acesso aos bancos de dados pertencentes à Biblioteca Virtual em Saúde (BVS), LILACS, MEDLINE, BDENF e PUBMED, durante o período de março a abril de 2017, o que resultou na Seleção de 11 estudos do processo de revisão. Conclusão: Fatores de risco para hipoglicemia durante infusão contínua de insulina: objetivo glicêmico rigoroso, suporte nutricional inadequado ou descontinuado, diabetes, falência orgânica, insuficiência renal aguda e crônica, hemodiálise, falta de padronização do trajeto de medição de glicemia, sepse, medicamentos vasoativos, atrasos nas medidas de glicose no sangue, ajustes inadequados no protocolo de insulina venosa, intervalos de verificação de insulina em 2h ou 4h, influência da hemoglobina glicosilada (HbA1c), doença hepática e dificuldades de aplicação e continuidade de Protocolos de monitoramento glicêmico e infusões. Assim, os profissionais que estão diretamente envolvidos com a terapia acima mencionada e o atendimento ao paciente assistido podem definir comportamentos que minimizam a ocorrência de hipoglicemia e óbitos(AU)

RESUMEN Introducción: La hipoglucemia es el efecto adverso más importante en los pacientes sometidos a la terapia de insulina endovenosa en la unidad de cuidados intensivos, por razón de su difícil control por los profesionales de salud, siendo también asociada a otros factores clínicos y patológicos de riesgo. Objetivo: Identificar en la literatura los factores de riesgo para la hipoglucemia durante la administración continua de insulina endovenosa. Métodos: Estudio de revisión integradora de la literatura. La recopilación de datos se llevó a cabo mediante el acceso a las bases de datos pertenecientes a la Biblioteca Virtual de Salud (BVS), LILACS, MEDLINE, BDENF y PUBMED, durante el período de marzo a abril de 2017, lo que resultó en la selección de 11 estudios a partir del proceso de revisión. Conclusión: Son factores de riesgo para hipoglucemia durante la infusión continua de insulina: objetivo glucémico riguroso, soporte nutricional inadecuado o descontinuado, diabetes, falencia orgánica, insuficiencia renal aguda y crónica, hemodiálisis, falta de estandarización de la vía de medición de la glucemia, sepsis, drogas vasoactivas, retrasos en las mediciones de la glucemia, ajustes inadecuados en el protocolo de insulina venosa, intervalos de verificación de insulina en 2h o 4h, influencia de la hemoglobina glicosilada (HbA1c), enfermedad hepática y las dificultades de aplicación y continuidad de los protocolos de vigilancia glucémica e infusiones. Siendo así, los profesionales que están directamente involucrados con la terapia mencionada y con la atención del paciente asistido podrán definir conductas que minimicen la ocurrencia de hipoglucemias y defunciones(AU)

ABSTRACT Introduction: Hypoglycemia is the most important adverse effect in patients undergoing intravenous insulin therapy in the intensive care unit, due to its difficult control by health professionals, also being associated with other clinical and pathological risk factors. Objective: To identify in the literature the risk factors for hypoglycemia during the continuous administration of intravenous insulin. Methods: Integrative review study of the literature. Data collection was carried out by accessing the databases belonging to the Virtual Health Library (VHL), LILACS, MEDLINE, BDENF, and PUBMED, during the period from March to April 2017, which resulted in the selection of 11 studies after the review process. Conclusion: Risk factors for hypoglycemia during continuous insulin infusion are rigorous glycemic objective, inadequate or discontinued nutritional support, diabetes, organic failure, acute and chronic renal failure, hemodialysis, lack of standardization of the blood glucose measurement pathway, sepsis, vasoactive drugs, delays in blood glucose measurements, inadequate adjustments in the venous insulin protocol, 2-4h insulin verification intervals, influence of glycosylated hemoglobin (HbA1c), liver disease, and difficulties in application and continuity of glycemic surveillance protocols and infusions. Thus, professionals who are directly involved with the aforementioned therapy and with the care for the assisted patient can define behaviors that minimize the occurrence of hypoglycemia and deaths(AU)

Prevalence and outcome of hypoglycemia in children attending emergency pediatric unit of a specialist hospital in Nigeria

Background: Hypoglycemia is a common metabolic problem encountered in pediatric emergency admissions. The absence of clinical symptoms does not preclude the presence of hypoglycemia as presentation may vary from asymptomatic to central nervous system and cardiopulmonary disturbances. If untreated, hypoglycemia can result in permanent neurological damage or even death. Objectives: The objective of the study is to determine the prevalence, associated factors and outcome of hypoglycemia in pediatric emergency admissions at Ahmad Sani Yariman Bakura Specialist Hospital, Gusau, Nigeria. Materials and Methods: The study was a prospective cross­sectional study involving children aged 1 month­13 years. Blood glucose was determined at admission using Accu­Chek® Active Blood Glucose Meter, and hypoglycemia was defined as blood glucose levels <2.8 mmol/L (<50 mg/dL). Age of the patients, sex, interval of last meal, presenting complaints diagnoses were recorded. Results: A total of 154 children were studied.Thirty (19.5%) were infants and 71 (46.1%) were under­fives. Eighty­seven (56.5%) were males with male to female ratio of 1.3:1.The prevalence of hypoglycemia was 22.1%. The predominant disease conditions the children with hypoglycemia presented with were severe malaria, acute diarrheal disease, and sepsis. The prevalence of hypoglycemia was significantly higher among children whose last meal was 8 h and above before presentation (42.9%). Children who presented with hypoglycemia were significantly more likely to die (odds ratio [OR] =13.3; 95% confidence interval [CI] =4.6­38.7). Among those with hypoglycemia, males were significantly more likely to die (OR = 4.2, 95% CI = 1.0­18.0). Hypoglycemia was significantly associated with mortality in children with severe malaria and pneumonia (P = 0.04 and 0.01, respectively). Conclusion: The prevalence of hypoglycemia is still high in our emergency admissions. It is associated with significant mortality especially among male children and those presenting with severe malaria and pneumonia. We recommend that hypoglycemia sought for and promptly treated in children presenting to emergency to reduce mortality

The coexistence of hypercalcemia and hypoglycemia in a patient with a renal tumor and B cell lymphoma

SUMMARY Paraneoplastic syndromes are a heterogeneous group of malignant diseases caused by events which involve endocrine, immune and metabolic aspects and whose symptoms vary according to the substance produced and the primary tumor. Hypercalcemia is a frequent complication in cancer patients. Prognosis of cancer patients with hypercalcemia is usually poor. A factor called parathyroid hormone related peptide, whose actions are similar to those of the parathyroid hormone, is thought to be the most common cause of malignancy associated hypercalcemia. Non-islet hypoglycemic cell tumor consists of a rare syndrome characterized by the presence of a solid tumor and severe fasting hypoglycemia determined by an insulin-independent pathway. We report a case of a 59-year-old-man with a renal tumor and a T-cell rich large B cell lymphoma who was hospitalized due to severe hypercalcemia and hypoglycemia. The laboratory examination reported hypercalcemia with inhibited PTH and hypoglycemia with inhibited insulin secretion, arriving to the conclusion of tumoral peptide production. He received denosumab and corticoid therapy. The patient died one month later despite initial improvement after medical treatment. While a single paraneoplastic manifestation may be expected in most tumors, the coexistence of two or more of them is rare, except in hepatocellular carcinomas, and it has not yet been described in renal tumors.

Factores asociados a hipoglucemia neonatal transitoria en recién nacidos sanos, en el Hospital Universitario San Ignacio, estudio de casos y controles / Case-Control Study Factors Associated with Transient Neonatal Hypoglycemia in Healthy Newborns, at Hospital Universitario San Ignacio

Objetivo: Determinar factores de riesgo asociados a hipoglucemia neonatal transitona en recién nacidos sanos. Materiales y métodos: Estudio de casos y controles anidados en una cohorte retrospectiva. Análisis de regresión logística. Resultados: Se evaluaron las variables de interés reportadas en la literatura en 40 casos y 40 controles. Se encontró como factor protector aislado para hipoglucemia el contacto piel a piel, que fue menor en los recién nacidos por cesárea; sin embargo, en el modelo de regresión logística, solamente el requerir fórmula láctea, por ineficaz lactancia materna, mostró ser un factor de nesgo para esta enfermedad (OR = 9). Conclusión: La ineficiente lactancia materna exclusiva es el mayor factor de riesgo para hipoglucemia neonatal transitoria en recién nacidos a término sanos, lo que ocasiona un aumento en el uso de fórmula láctea.

Objective: lo determinare risk factors associated to neonatal hypoglycemia in healthy newboms. Materials and methods: Case-control study nested in a retrospective cohort. Logistic regression analysis. Results: 40 cases and 40 Controls were evaluated. The main risk factors according to the literature were reported. Skin to skin care was found as an ¿solated protective factor to develop neonatal hypoglycemia, although, the regression logistic analysis showed, that only the need to enhance feedmg with formula was a risk factor to develop neonatal hypoglycemia (OR=9). Conclusión: Inadequate exclusive breastfeeding remains the major risk factor for transient neonatal hypoglycaemia in healthy term newbom, leading to increased use of formula.

Risk factors for unstable blood glucose level: integrative review of the risk factors related to the nursing diagnosis / Risco de glicemia instável: revisão integrativa dos fatores de risco do diagnóstico de enfermagem / Riesgo de nivel de glucemia inestable: revisión integradora de los factores de riesgo del diagnóstico de enfermeira

ABSTRACT Objective: to identify evidence in the literature on the possible risk factors for the risk of unstable blood glucose diagnosis in individuals with type 2 diabetes mellitus, and to compare them with the risk factors described by NANDA International. Method: an integrative literature review guided by the question: what are the risk factors for unstable blood glucose level in people with type 2 diabetes mellitus? Primary studies were included whose outcomes were variations in glycemic levels, published in English, Portuguese or Spanish, in PubMed or CINAHL between 2010 and 2015. Results: altered levels of glycated hemoglobin, body mass index>31 kg/m2, previous history of hypoglycemia, cognitive deficit/dementia, autonomic cardiovascular neuropathy, comorbidities and weight loss corresponded to risk factors described in NANDA International. Other risk factors identified were: advanced age, black skin color, longer length of diabetes diagnosis, daytime sleepiness, macroalbuminuria, genetic polymorphisms, insulin therapy, use of oral antidiabetics, and use of metoclopramide, inadequate physical activity and low fasting glycemia. Conclusions: risk factors for the diagnosis, risk for unstable blood glucose level, for persons with type 2 diabetes mellitus were identified, and 42% of them corresponded to those of NANDA International. These findings may contribute to the practice of clinical nurses in preventing the deleterious effects of glycemic variation.

RESUMO Objetivo: identificar evidências na literatura acerca de possíveis fatores de risco do diagnóstico risco de glicemia instável para pessoas com diabetes mellitus tipo 2 e compará-los com os fatores de risco descritos pela NANDA International . Método: revisão integrativa norteada pela pergunta: quais são os fatores de risco de glicemia instável em pessoas com diabetes mellitus tipo 2? Incluíram-se estudos primários cujos desfechos eram variações nos níveis glicêmicos, publicados em inglês, português ou espanhol no PubMed ou CINAHL entre 2010 e 2015. Resultados: observou-se que alteração nos níveis de hemoglobina glicada, índice de massa corpórea>31 Kg/m2, história prévia de hipoglicemia, déficit cognitivo/demência, neuropatia autonômica cardiovascular, comorbidades e perda de peso correspondiam a fatores de risco descritos pela NANDA International . Outros fatores de risco identificados foram: idade avançada, raça negra, maior tempo de diagnóstico de diabetes, sonolência diurna, macroalbuminúria, polimorfismos genéticos, insulinoterapia, uso de antidiabéticos orais, uso de metoclopramida, atividade física inadequada e glicemia de jejum baixa. Conclusões: identificaram-se fatores de risco do diagnóstico risco de glicemia instável para pessoas com diabetes mellitus tipo 2, dos quais 42% correspondiam àqueles da NANDA International . Esses achados podem contribuir para a prática de enfermeiros clínicos na prevenção dos efeitos deletérios da variação glicêmica.

RESUMEN Objetivo: identificar evidencias en la literatura acerca de posibles factores de riesgo del diagnóstico "riesgo de nivel de glucemia inestable" para personas con diabetes mellitus tipo 2 y compararlos con los factores de riesgo descritos por la NANDA International . Método: revisión integradora orientada por la pregunta: ¿Cuáles son los factores de riesgo de nivel de glucemia inestable en personas con diabetes mellitus tipo 2? Se incluyeron estudios primarios cuyos resultados eran variaciones en los niveles glucémicos, publicados en inglés, portugués o español en el PubMed o CINAHL entre 2010 y 2015. Resultados: se observó que una alteración en los niveles de: hemoglobina glucosilada, índice de masa corporal >31 Kg/m2, historia previa de hipoglucemia, déficit cognitivo/demencia, neuropatía autonómica cardiovascular, comorbilidades y pérdida de peso, correspondían a factores de riesgo descritos por la NANDA International . Otros factores de riesgo identificados fueron: edad avanzada, raza negra, mayor tiempo de diagnóstico de diabetes, somnolencia diurna, macroalbuminuria, polimorfismos genéticos, insulinoterapia, uso de antidiabéticos orales, uso de metoclopramida, actividad física inadecuada y glucemia de ayuno baja. Conclusiones: se identificaron factores de riesgo del diagnóstico riesgo de nivel de glucemia inestable para personas con diabetes mellitus tipo 2, de los cuales 42% correspondían a los de la NANDA International . Esos hallazgos pueden contribuir para la práctica de enfermeros clínicos en la prevención de los efectos deletéreos de la variación glucémica.

Emergências glicêmicas / Glycemic emergencies

Emergências glicêmicas são complicações frequentes na prática do emergencista, constituindo importante causa de morbimortalidade. Este capítulo objetiva abordar de forma prática o diagnóstico e o manejo das emergências glicêmicas mais comuns em sala de emergência.

Glycemic emergencies are frequent complications in the practice of the emergencist physician, and it is an important cause of morbidity and mortality. This chapter aims to approach in a practical way the diagnosis and management of the most common glycemic emergencies in the emergency room.

Hypoglycaemia in Children: Review of the Literature

Hypoglycaemia is a common metabolic condition in children. It often presents urgent and therapeutic challenges and it has been documented to affect many childhood conditions. Its clinical presentation is not classical and requires a high index of suspicion for an early diagnosis and prompt management. Undiagnosed or undertreated hypoglycaemia has been found to increase mortality in children when it is present. This review sought to review the subject of hypoglycaemia in children and calls for testing for it in all sick and admitted children

Multiple Endocrine Neoplasia Type 1 Presenting as Hypoglycemia due to Insulinoma

Multiple endocrine neoplasia (MEN) mutation is an autosomal dominant disorder characterized by the occurrence of parathyroid, pancreatic islet, and anterior pituitary tumors. The incidence of insulinoma in MEN is relatively uncommon, and there have been a few cases of MEN manifested with insulinoma as the first symptom in children. We experienced a 9-year-old girl having a familial MEN1 mutation. She complained of dizziness, occasional palpitation, weakness, hunger, sweating, and generalized tonic-clonic seizure that lasted for 5 minutes early in the morning. At first, she was only diagnosed with insulinoma by abdominal magnetic resonance images of a 1.3 × 1.5 cm mass in the pancreas and high insulin levels in blood of the hepatic vein, but after her father was diagnosed with MEN1. We found she had familial MEN1 mutation, and she recovered hyperinsulinemic hypoglycemia after enucleation of the mass. Therefore, the early genetic identification of MEN1 mutation is considerable for children with at least one manifestation.

Energy intake underreporting of adults in a household survey: the impact of using a population specific basal metabolic rate equation / Subestimativa da ingestão energética em amostra probabilística de adultos: o impacto do uso de equações específicas para taxa metabólica basal / Subestimación de la ingesta energética en una muestra probabilística de adultos: el impacto del uso de ecuaciones específicas para la tasa metabólica basal

The purpose of the present study was to identify energy intake (EI) underreporting and to estimate the impact of using a population specific equation for the basal metabolic rate (BMR) in a probability sample of adults from Niterói, Rio de Janeiro State, Brazil. A sample of 1,726 subjects participated in the study. EI was assessed by a 24-hour dietary recall and EI/BMR was computed with BMR estimated using internationally recommended equations as well as specific equations developed for the adult population of Niterói. Mean EI was 1,570.9 and 2,188.8kcal.day-1 for women and men, respectively. EI decreased with increasing age in both men and women. BMR estimated by the Brazilian equation was significantly lower than the values estimated by the international equation for all age, sex and nutritional status groups. In general, EI underreporting was found in at least 50% of the population, higher in women, and increased with increasing age and body mass index (BMI). The results of the present study confirm that EI is underreported, even when BMR is estimated using population-specific equations.

O objetivo do presente estudo foi identificar a subestimativa da ingestão energética (IE) e estimar o impacto do uso de uma equação específica da população para a taxa metabólica basal (TMB), em amostra probabilística de adultos do Município de Niterói, Rio de Janeiro, Brasil. Uma amostra de 1.726 indivíduos da população adulta participou do estudo. Ingestão energética foi avaliada por um recordatório de 24 horas e IE/TMB foi calculada com TMB estimada pelas equações recomendadas e pelas equações específicas para a população. A média da IE foi 1.570,9 e 2.188,8kcal.dia-1 em mulheres e homens, respectivamente. A ingestão energética diminuiu com o aumento da idade em homens e mulheres. A taxa metabólica basal estimada pela equação brasileira foi significativamente menor do que os valores estimados pela equação recomendada para todas as idades, sexo e estado nutricional. Em geral, a subestimativa da IE foi encontrada em pelo menos 50% da população, maior em mulheres, e aumentou com o avanço da idade e índice de massa corporal (IMC). Os resultados confirmam que IE é subestimada, mesmo quando a TMB é estimada pelas equações da população específica.

El objetivo del presente estudio fue identificar la subestimación de la ingesta energética (IE) y estimar el impacto del uso de una ecuación específica de la población para la tasa metabólica basal (TMB), en una muestra probabilística de adultos del municipio de Niterói, Río de Janeiro, Brasil. Una muestra de 1.726 individuos de la población adulta participó en el estudio. La ingesta energética fue evaluada mediante un recordatorio de 24 horas y las IE/TMB fueron calculadas con una TMB estimada por las ecuaciones recomendadas y por las ecuaciones específicas para la población. La media de la IE fue 1.570,9 y 2.188,8kcal.día-1 en mujeres y hombres, respectivamente. La ingesta energética disminuyó con el aumento de la edad en hombres y mujeres. La tasa metabólica basal estimada por la ecuación brasileña fue significativamente menor que los valores estimados por la ecuación recomendada para todas las edades, sexo y estado nutricional. En general, la subestimación de la IE se encontró en por lo menos un 50% de la población, fue mayor en mujeres y aumentó con el aumento de la edad e índice de masa corporal (IMC). Los resultados confirman que la IE está subestimada, incluso cuando la TMB está estimada por las ecuaciones de población específica.

Risk of hypoglycemia during hemodialysis in diabetic patients is related to lower pre-dialysis glycemia

Objective To compare the occurrence of hypoglycemia during hemodialysis in chronic kidney disease diabetic patients who present different levels of pre-dialysis glycemia both when using dialysis solutions with and without glucose. Subjects and methods Twenty type 2 diabetic patients in maintenance hemodialysis were submitted to three dialysis sessions (at a 7-day interval each) with dialysis solutions without glucose, with glucose at 55 mg/dL, and at 90 mg/dL subsequently. Blood glucose levels were measured immediately pre-dialysis and at 4 moments during the session, and values under 70 mg/dL were considered as hypoglycemia. Results Average pre-dialysis glycemia was lower in those who presented intra-dialytic hypoglycemia than in those who did not, both in glucose-free (140.4 ± 50.7 vs. 277.7 ± 91.0 mg/dL; p = 0.005; 95%CI: 46.4 to 228.1) and in glucose 55 mg/dL (89.5 ± 10.6 vs. 229.7 ± 105.0 mg/dL; p < 0.05; 95%CI: 9.8 to 270.5). In patients with pre-dialysis glycemia under 140 mg/dL, average intradialytic glycemia was significantly lower than pre-dialysis glycemia only when using glucose-free dialysate (p < 0.0001; 95%CI: 29.9 to 56.0 - t-test). Hypoglycemia during dialysis was observed only when using glucose-free or glucose-poor dialysis solutions. Conclusions The use of glucose-free or glucose-poor dialysis solution presents a high risk of intradialytic hypoglycemia in diabetic renal patients, especially in those with presumed better glycemic control. .

Glucogénesis: caracterización clínica - patológica del primer caso descrito en Bolivia en un paciente pediátrico / Glycogen storage disease: first clinicopathologic pediatric case described in Bolivia

Las glucogenosis son enfermedades hereditarias del metabolismo del glucógeno. Se reconocen más de 12 tipos y afectan principalmente al hígado y al músculo, mismas que se clasifican según la enzima defectuosa y el órgano afectado. Presentamos el caso de un niño de 4 años y 6 meses con hepatomegalia importante, retardo del crecimiento pondoestatural, extremidades delgadas, facies con mejillas redondas. Sus exámenes laboratoriales revelaron: hipoglicemia, hiperlipidemia, hiperuricemia y sus estudios imagenológicos evidenciaron hepatomegalia difusa severa. El estudio histopatológico concluyó con glucogenosis, no pudiendo definirse el tipo, por la imposibilidad de realizar pruebas específicas de histoquímica en Bolivia. El paciente es seguido por consulta externa, bajo indicaciones dietéticas para prevenir complicaciones.

Glycogen storage diseases are inherited metabolic disorders of glycogen metabolism. There are over 12 types, they may affect primarily the liver and muscle. They are classified and the affected tissue. The case of a 4 y 6m old-male infant is presented, with growth retardation, thin limbs, rounded cheeks. Laboratory testing showed hypoglycemia, hyperlipidermia, hyperuricemia. Imagenoly testing showed severe diffuse hepatomegaly. Histopathology concluded in glycogen storage disease, the enzyme deficiency could not be established because of the unavailability of these test in Bolivia. The patient is followed by consult, diet therapy to prevent complications.

Hipoglicemia em adultos / Hypoglycemia in adults

A hipoglicemia é um evento potencialmente grave, com significativa morbidade. É rara em indivíduos sem diabetes, e pode ocorrer com frequência variável em pacientes com diabetes mellitus, especialmente naqueles que utilizam insulina. Para minimizar esse risco é imprescindível que se individualize o tratamento, estabelecendo metas glicêmicas de acordo com a idade, expectativa de vida, comorbidades e estilo de vida

Hypoglycemia is a potentially serious event with significant morbidity. It is rare in individuals without diabetes and can occur in a quite variable frequency in diabetic patients, especially in those that use insulin. In order to minimize its risk in these groups, it is essential to individualize treatment, establishing glycemic targets according to age, life expectancy, comorbidities and lifestyle

Spurious Elevation of Glucose Concentration during Administration of High Dose of Ascorbic Acid in a Patient with Type 2 Diabetes on Hemodialysis

We describe herein a case of life-threatening hypoglycemia due to spurious elevation of glucose concentration during the administration of ascorbic acid in a type 2 diabetic patient. A 31-year-old female was admitted for proliferative diabetic retinopathy treatment and prescribed high dose ascorbic acid. During hospitalization, she suddenly lost her consciousness and her glucose concentration was 291 mg/dL, measured using self-monitoring blood glucose (SMBG) device, while venous blood glucose concentration was 12 mg/dL. After intravenous injection of 50% glucose solution, the patient became alert. We reasoned that glucose measurement by SMBG device was interfered by ascorbic acid. Physicians should be aware of this interference; high dose ascorbic acid may cause spurious elevation of glucose concentration when measuring with SMBG devices.

Síndrome de Doege-Potter: hipoglicemia secundaria a tumor fibroso solitario de la pleura / Doege-Potter syndrome: hypoglycemia secondary to solitary fibrous tumor of the pleura. Report of one case

Doege-Potter syndrome is characterized for hypoglycemia associated with solitary pleural fibrous tumors. We report a 38-year-old woman with a history of weight loss, malaise and edema. After an episode of symptomatic hypoglycemia, she was admitted to the hospital, where she had new episodes of hypoglycemia. A Chest X ray and scan showed a right pleural tumor that was surgically excised. After surgery the episodes of hypoglycemia subsided. The pathological study of the tumor revealed a solitary fibrous pleural tumor. After 15 months of follow up, the patient is symptom free and without evidence of tumor relapse.

Diagnóstico y manejo de la hipoglicemia en adultos diabéticos hospitalizados: evaluación de competencias en un equipo profesional multidisciplinario de salud / Competences on hypoglycemia management among healthcare professionals in a clinical hospital

Background: A tight glycemic control of hospitalized patients increases the risk of hypoglycemia, whose management is not always optimal. Aim: To assess the hypoglycemia management competences of a multidisciplinary team in a clinical hospital. Material and Methods: An anonymous questionnaire about hypoglycemia management was answered by 11 staff physicians, 42 residents and 28 nurses of the department of medicine and critical care unit ofa university hospital. Results: Respondents had a mean of 60 percent of correct answers, without significant differences between groups. The capillary blood glucose level that defines hypoglycemia was known by most of the respondents, but the value that defines severe episodes was known only by 60 percent. The initial management and follow up was well known only for severe episodes. Less than 50 percento knew the blood glucose value that required continuing with treatment. Conclusions: Although most professionals are able to recognize hypoglycemia, the knowledge about is management if insufficient.